The Design of an Effective, Economical Executive Information System For Cedarville College

The managers of a corporation have an obligation to make the best use of available organizational resources for daily operational activities of the corporation and for long-range development. This requirement for efficient management certainly obtains for higher education, as declining student populations and shrinking funding sources argue for an even greater need to manage well. One important aspect of efficient management is having sufficient information for decision making. This dissertation addresses the need for electronic tools to assist officers of a higher education institution in the management of the institution by improving access to information. College administrators need information about the status of their institution, projections of enrollment and funding, and comparative data from other institutions. This dissertation presents a systems analysis model for provision of that management data in the form of an executive information system (EIS). A review of the literature on executive information systems reveals extensive EIS activity in the commercial environment, but very little EIS activity within higher education. Recent declines in hardware pricing and the appearance of economical productivity software have made the development of an EIS more feasible within higher education. The literature review includes a discussion of information requirements for executives, historical development of executive information systems, and commercial executive information systems. The design section of the dissertation presents a framework for development of an EIS for Cedarville College. The recent installation of a campus-wide network has provided desktop computing access to administrative officers of the college, but there is not yet an appropriate software system which would utilize this network for administrative information delivery. The design framework includes a requirements analysis, a preliminary feasibility study, testing procedures, and an implementation plan for the development of an executive information system for Cedarville College. The requirements analysis performed as part of the study are based on interviews with administrators and middle-managers at Cedarville College. The identified requirements include a description of major decision making to be supported and the types of data which are typically used in support of that decision making. Following the requirements analysis, the author presents a review of five commercially-available EIS software packages. The review includes a description of each product, pricing information, and an overview of the data structures used by each product. As part of the analysis procedure, a prototype EIS was designed and implemented in three of the packages. The entire EIS design and prototype implementations were reviewed by Cedarville College participants and by four external reviewers. The systems analysis efforts performed as part of this study have resulted in an increased awareness of information requirements within the College administration and middle-management. The proposed EIS design and corresponding prototypes have demonstrated the feasibility of improving executive information support within the College. Such a design can provide an effective EIS for Cedarville College. However, development of the EIS prototypes has highlighted the importance of continued active participation by executives and systems analysts in the ongoing evolution of the executive information system. While EIS software costs can be identified and kept within a fairly small budget, personnel support issues may outweigh any software costs involved in an EIS project. Thus, delivery of an economical EIS for Cedarville College and other similar colleges remains an area for ongoing research

The Bond-Algebraic Approach to Dualities

An algebraic theory of dualities is developed based on the notion of bond algebras. It deals with classical and quantum dualities in a unified fashion explaining the precise connection between quantum dualities and the low temperature (strong-coupling)/high temperature (weak-coupling) dualities of classical statistical mechanics (or (Euclidean) path integrals). Its range of applications includes discrete lattice, continuum field, and gauge theories. Dualities are revealed to be local, structure-preserving mappings between model-specific bond algebras that can be implemented as unitary transformations, or partial isometries if gauge symmetries are involved. This characterization permits to search systematically for dualities and self-dualities in quantum models of arbitrary system size, dimensionality and complexity, and any classical model admitting a transfer matrix representation. Dualities like exact dimensional reduction, emergent, and gauge-reducing dualities that solve gauge constraints can be easily understood in terms of mappings of bond algebras. As a new example, we show that the (\mathbb{Z}_2) Higgs model is dual to the extended toric code model {\it in any number of dimensions}. Non-local dual variables and Jordan-Wigner dictionaries are derived from the local mappings of bond algebras. Our bond-algebraic approach goes beyond the standard approach to classical dualities, and could help resolve the long standing problem of obtaining duality transformations for lattice non-Abelian models. As an illustration, we present new dualities in any spatial dimension for the quantum Heisenberg model. Finally, we discuss various applications including location of phase boundaries, spectral behavior and, notably, we show how bond-algebraic dualities help constrain and realize fermionization in an arbitrary number of spatial dimensions.Comment: 131 pages, 22 figures. Submitted to Advances in Physics. Second version including a new section on the eight-vertex model and the correction of several typo

The atm-1 gene is required for genome stability in Caenorhabditis elegans

The Ataxia-telangiectasia-mutated (ATM) gene in humans was identified as the basis of a rare autosomal disorder leading to cancer susceptibility and is now well known as an important signal transducer in response to DNA damage. An approach to understanding the conserved functions of this gene is provided by the model system, Caenorhabditis elegans. In this paper we describe the structure and loss of function phenotype of the ortholog atm-1. Using bioinformatic and molecular analysis we show that the atm-1 gene was previously misannotated. We find that the transcript is in fact a product of three gene predictions, Y48G1BL.2 (atm-1), K10E9.1, and F56C11.4 that together make up the complete coding region of ATM-1. We also characterize animals that are mutant for two available knockout alleles, gk186 and tm5027. As expected, atm-1 mutant animals are sensitive to ionizing radiation. In addition, however, atm-1 mutants also display phenotypes associated with genomic instability, including low brood size, reduced viability and sterility. We document several chromosomal fusions arising from atm-1 mutant animals. This is the first time a mutator phenotype has been described for atm-1 in C. elegans. Finally we demonstrate the use of a balancer system to screen for and capture atm-1-derived mutational events. Our study establishes C. elegans as a model for the study of ATM as a mutator potentially leading to the development of screens to identify therapeutic targets in humans

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome

<p><u>(A) Circular map of the <i>E</i>. <i>coli</i> chromosome</u>: <i>oriC</i>, <i>dif</i> and <i>terD</i> to <i>terB</i> sites are indicated. Numbers refer to the chromosome coordinates (in kb) of MG1655. (<u>B) Linear map of the terminus region:</u> chromosome coordinates are shown increasing from left to right, as in the marker frequency panels (see Figure 1C for example), therefore in the opposite direction to the circular map. In addition to <i>dif</i> and <i>ter</i> sites, the positions of the <i>parS</i>_pMT1 sites used for microscopy experiments are indicated. (<u>C) MFA analysis of terminus DNA loss in the <i>recB</i> mutant</u>: sequence read frequencies of exponential phase cells normalized to the total number of reads were calculated for each strain. Ratios of normalized reads in isogenic wild-type and <i>recB</i> mutant are plotted against chromosomal coordinates (in kb). The profile ratio of the terminus region is enlarged and the profile of the corresponding entire chromosomes is shown in inset. Original normalized profiles used to calculate ratios are shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007256#pgen.1007256.s005" target="_blank">S1 Fig</a>. The position of <i>dif</i> is indicated by a red arrow. The <i>ter</i> sites that arrest clockwise forks (<i>terC</i>, <i>terB</i>, green arrow) and counter-clockwise forks (<i>terA</i>, <i>terD</i>, blue arrow) are shown. <u>(D) Schematic representation of focus loss in the <i>recB</i> mutant:</u> Time-lapse microscopy experiments showed that loss of a focus in the <i>recB</i> mutant occurs concomitantly with cell division in one of two daughter cells, and that the cell that keeps the focus then generates a focus-less cell at each generation. The percentage of initial events was calculated as the percentage of cell divisions that generate a focus-less cell, not counting the following generations. In this schematic representation, two initial events occurred (generations #2 and #7) out of 9 generations, and focus loss at generation #2 is heritable. Panels shown in this figure were previously published in [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007256#pgen.1007256.ref019" target="_blank">19</a>] and are reproduced here to introduce the phenomenon.</p

Introduction: Toward an Engaged Feminist Heritage Praxis

We advocate a feminist approach to archaeological heritage work in order to transform heritage practice and the production of archaeological knowledge. We use an engaged feminist standpoint and situate intersubjectivity and intersectionality as critical components of this practice. An engaged feminist approach to heritage work allows the discipline to consider women’s, men’s, and gender non-conforming persons’ positions in the field, to reveal their contributions, to develop critical pedagogical approaches, and to rethink forms of representation. Throughout, we emphasize the intellectual labor of women of color, queer and gender non-conforming persons, and early white feminists in archaeology

Think Again – Supplying War: Reappraising Military Logistics and Its Centrality to Strategy and War

This article argues that logistics constrains strategic opportunity while itself being heavily circumscribed by strategic and operational planning. With the academic literature all but ignoring the centrality of logistics to strategy and war, this article argues for a reappraisal of the critical role of military logistics, and posits that the study and conduct of war and strategy are incomplete at best or false at worst when they ignore this crucial component of the art of war. The article conceptualises the logistics–strategy nexus in a novel way, explores its contemporary manifestation in an age of uncertainty, and applies it to a detailed case study of UK operations in Iraq and Afghanistan since 2001